• Backbone structures are obtained using ProteinViewer, where N-terminal is colored red and C-terminal blue.
• Click the images to view larger image.
• Click PDB IDs to view the corresponding PDB file
• See the bottom for brief explanation of the DSSP codes and the 5-tile codes. 
• The "site" row indicates active site residues:
          "*" denotes active sites registered in SwissProt/UniProt.
          "+" denotes active sites registered in PROSITE/UniProt.
           Residues registered in both of them are denoted by "*."
• In the images of superimposition, the C-terminal of the first sequence is connected with the N-terminal of the second sequecne
  (because of the DaliLite output format).
  

(1) Cluster 41

				Z-Score: 13.4 AR: 84 RMSD: 6.0A SI: 98%
1mxe A (len 144)	1ooj A (len 141)		DaliLite result

site                ************+                       ** **********+ 1mxe LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDA DGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVF code --QAAAAAAAAAAAAABQBRRRG00QAAAAAAAAABR0000QAAAAAAAAABRQ BRRRG00QAAAAAAAAAAAG0GRQAAAAAAAAAAA LCS     AAAAAAAAAAAAABQBRRRG00QAAAAAAAAABR 000QAAAAAAAA B   BRR G00QAAAAAAAAAAA     AAAAAAAAAAA code  --AAAAAAAAAAAAABQBRRRG00QAAAAAAAAABRG000QAAAAAAAA B1G1BRR0G00QAAAAAAAAAAAAAAAAAAAAAAAAAAA 1ooj  TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIN EVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVF site                ************+                       ** **********+  site ************+         *             ************+ 1mxe DKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTS code BQBRRRG00QAAAAAAAAABR0R00QAAAAAAAAAB8QBRRRG00QAAAAAAA-- LCS  BQBRRRG00QAAAAAAAAABR0 00QAAAAAAAAAB QBRR G00QAAAAA code BQBRRRG00QAAAAAAAAABR0000QAAAAAAAAABRQBRR0G00QAAAAA-- 1ooj DKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMM site ************+         *             ************+ *RATIO :  lcs/trimmed_seq_a = 0.886 (=  124/  140), lcs/trimmed_seq_b = 0.905 (=  124/  137)

Structural alignment by ComSubstruct + manual inspection

DSSP lLHHHHHHHHHHHHHHLLLLLLEELHHHHHHHHHHLLLLLLHHHHHHHHHHHLLLLLLLEEHHHHHHHHHHHHHHLLHHHhhhhhhhhh 1mxe lTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEeireafrvf       ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1ooj .TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEE.........  DSSP .LLLHHHHHHHHHHHHLLLLLLEELHHHHHHHHHHLLLLLLHHHHHHHHHLLLLLLLLLEEHHHHHHHHHHHHHHHHHHH......... DSSP lllllleelhhhhhhhhhhllllllhhhhhhhhhhhlLLLLL..................................leehhhhhhhhhl 1mxe dkdgngfisaaelrhvmtnlgekltdeevdemireadIDGDG..................................qvnyeefvtmmts                                            || | 1ooj ...........................eireafrvfdKDGNGfisaaelrhvmtnlgekltdeevdemireadidgdgqvnyeefvtmm DSSP ...........................hhhhhhhhhlLLLLLeelhhhhhhhhhlllllllhhhhhhhhhhhllllllleehhhhhhhl *Z-score 13.4  AR 84  RMSD 6.0A  SI 98%

Structural alignment by DaliLite

				Z-Score: 14.0 AR: 84 RMSD: 7.9A SI: 100%
1mxe A (len 144)	4cln (len 148)		DaliLite result

site                   ************+                       ************+ 1mxe    LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVF code    --QAAAAAAAAAAAAABQBRRRG00QAAAAAAAAABR0000QAAAAAAAAABRQBRRRG00QAAAAAAAAAAAG0GRQAAAAAAAAAAA LCS       QAAAAAAAAAA AABQBRR G00QAAAAAAAAAB 0000QAAAAAAAAABRQ  RRG00QAAAAAAAAAAA     AAAAAAAAAAA code --R00QAAAAAAAAAAHAABQBRR0G00QAAAAAAAAAB30000QAAAAAAAAABRQ80RRG00QAAAAAAAAAAA     AAAAAAAAAAA 4cln ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKM     KDTDSEEEIRE site                   ************+                       ************+ site      ************+         *              ************+ 1mxe      DKDGNGFISAAELRHVMTNLGEK LTDEEVDEMIREADIDGDGQVNYEEFVTM MTS code      BQBRRRG00QAAAAAAAAABR0R 00QAAAAAAAAAB8QBRRRG00QAAAAAA A-- LCS       BQBRR G00QAAAAAAAA B 0  00QAAAAAAAAAB QBRRRG00QAAAA   A code AAAAABQBRR0G00QAAAAAAAA BG00000QAAAAAAAAABGQBRRRG00QAAAAB1QA-- 4cln AFRVFDKDGNGFISAAELRHVMT NLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK site      ************+          *             ************+ *RATIO :  lcs/trimmed_seq_a = 0.879 (=  123/  140), lcs/trimmed_seq_b = 0.854 (=  123/  144)

Structural alignment by ComSubstruct + manual inspection

DSSP ...LLHHHHHHHHHHHHHHLLLLLLEELHHHHHHHHHHLLLLLLHHHHHHHHHHHLLLLLLLEEHHHHHHHHHHHHHHLLHHHhhhhhhhhh 1mxe ...LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEeireafrvf         |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 4cln adqLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEeireafrvf  DSSP lllLLHHHHHHHHHHHHHHLLLLLLEELHHHHHHHHHHLLLLLLHHHHHHHHHHHLLLLLLLEEHHHHHHHHHHHHHHHHHHHhhhhhhhhh DSSP lllllleelhhhhhhhhhhllllllhhhhhhhhhhhlLLLL.lleehhhhhhhhhl 1mxe dkdgngfisaaelrhvmtnlgekltdeevdemireadIDGD.gqvnyeefvtmmts                                           |||| 4cln dkdgngfisaaelrhvmtnlgekltdeevdemireadIDGDgqvnyeefvtmmtsk DSSP lllllllllhhhhhhhhhhhlllllhhhhhhhhhlllLLLLllllhhhhhhhllll *Z-score 14.0  AR 84  RMSD 7.9A  SI 100%

Structural alignment by DaliLite

(2) Cluster 42

				Z-Score: 55.8 AR: 311 RMSD: 0.6A SI: 100%
1oao C (len 729)	1oao D (len 728)		DaliLite result

site  1oaC MTDFDKIFEGAIPEGKEPVALFREVYHGAITATSYAEILLNQAIRTYGPDHPVGYPDTAYYLPVIRCF SGEEVKKLGDLPPILNRKRAQV code --QAAAABGRRG00RG0RQAAAAAAAAAAAAAAAAAAAAAAAAAAG00QBG0000030QG0RPAAAG8 000R000QABHQAAAAAAAABR LCS     AAAABGRRG00R 0RQAAAAAAAAAAAAAAAAAAAAAAAAAAG00QBG00000 0Q 0R AAA 8 000R000QABHQAAAAAAAABR code  --AAAABGRRG00RR0RQAAAAAAAAAAAAAAAAAAAAAAAAAAG00QBG0000000QB0R1AAA 80000R000QABHQAAAAAAAABR 1oaD  TDFDKIFEGAIPEGKEPVALFREVYHGAITATSYAEILLNQAIRTYGPDHPVGYPDTAYYLPVIR CFSGEEVKKLGDLPPILNRKRAQV site site  1oaC SPVLNFENARLAGEATWYAAEIIEALRYLKYKPDEPLLPPPWTGFIGDPVVRRFGIKMVDWTI   PGEAIILGRAKDSKALAKIVKELMGMG code 0RB00QAAAAAAAAAAAAAAAAAAAAAAABG0QAG0R000OG00000QAAAAAAQAAAABRQB   R000000000R0QAAAAAAAAAAAABR LCS  0R 00QAAAAAAAAAAAAAAAAAAAAAAABG0QAG0R000OG0 000QAAAA    AAAB  B   R000000000R0QAAAAAAAAAAAABR code 0RR00QAAAAAAAAAAAAAAAAAAAAAAABG0QAG0R000OG0O000QAAAA01  AAAB1 BRR0R000000000R0QAAAAAAAAAAAABR 1oaD SPVLNFENARLAGEATWYAAEIIEALRYLKYKPDEPLLPPPWTGFIGDPVVRRF  GIKMV DWTIPGEAIILGRAKDSKALAKIVKELMGMG site  site  1oaC FMLFICDEAVEQLLEENVKLGIDYIAYPLGNFTQIVHAANYALRAG MMFGGVTPGAREEQRDYQRRRIRAFVLYLGEHDMVKTAAAFGAI code 0000000QAAAAAAABR0000QABRG0RR000QAAAAAAAAAAAAA B0QBR000RRQAAAAAAAA01RR0000000000QAAAAAAAAAA LCS  0000000QAAAAAAABR0000QABRG0RR000QAAAAAAAAAAAAA B  BR000RR AAAAAAAA 1 R0000000000QAAAAAAAAAA code 0000000QAAAAAAABR0000QABRG0RR000QAAAAAAAAAAAAA1B1 BR000RR1AAAAAAAAB10R0000000000QAAAAAAAAAA 1oaD FMLFICDEAVEQLLEENVKLGIDYIAYPLGNFTQIVHAANYALRAGMMF GGVTPGAREEQRDYQRRRIRAFVLYLGEHDMVKTAAAFGAI site  site  1oaC FTGFPVITDQPLPEDKQIPDWFFSVEDYDKIVQIAMETRGI KLTKIKLDLPINFGPAFEGE  SIRKGDMYVEMG GNRTPAFELVRTVSESE code AB300000RG000QA8G00RG0000RGQAHQAAAAAAABR0 00RR0R000RG000QAAABG  000QABGR0001 RQB00000000000QAB LCS  AB 00000RG000QA G00RG0000RGQA QAAAAAAABR0 00  0 000RG000QA  B   000QABGR000  R  00000000000QAB code ABR00000RG000QABG00RG0000RGQAJQAAAAAAABR0300000 000RG000QA  BHR0000QABGR00000RG 00000000000QAB 1oaD FTGFPVITDQPLPEDKQIPDWFFSVEDYDKIVQIAMETRGIKLTKIK LDLPINFGPA  FEGESIRKGDMYVEMGGNR TPAFELVRTVSESE site  site                       ++++++++++++++++++ 1oaC ITDGKIEVIGPDIDQIPEGSKLPLGILVDIYGRKMQADFEGVLERRIHDFINYGEGLWHTGQRNINWLRVSKDAVAKGFRFKNYGEILVA code 000R00000000QABG00R0000000000000Q000QAAAAAAAAAAAAAAABG0RG000000QB000000QAAAAB000QAAAAAAAAA LCS   00R00000000QABG00R0000000000000Q 00QAAAAAAAAAAAAAAABG0RG000000QB000000QAAAAB000QAAAAAAAAA code G00R00000000QABG00R0000000000000QB00QAAAAAAAAAAAAAAABG0RG000000QB000000QAAAAB000QAAAAAAAAA 1oaD ITDGKIEVIGPDIDQIPEGSKLPLGILVDIYGRKMQADFEGVLERRIHDFINYGEGLWHTGQRNINWLRVSKDAVAKGFRFKNYGEILVA site                       ++++++++++++++++++ site                                                       *  *        *         * 1oaC KMKEEFPAIVDRVQVTIFTDEAKVKEYMEVAREKYKERDDRMRGLTDETVDTFYSCVLCQSFAPNHVCIVTPERVGLCGAVSWLDAKASY code AAAAB00QBGR0000000RGQAAAAHAAAAAAAAAAAAAAAAABG0QABGRG0000RQAQB00QB000000QBG00QBRGG0QAAAAAAA LCS  AAAAB00QBGR0000000RGQAAAA AAAAAAAAAAAAAAAAABG0Q BGRG0000RQAQB0 QB000000QBG00QBRGG0QAAAAAAA code AAAAB00QBGR0000000RGQAAAAAAAAAAAAAAAAAAAAAABG0Q9BGRG0000RQAQB0BQB000000QBG00QBRGG0QAAAAAAA 1oaD KMKEEFPAIVDRVQVTIFTDEAKVKEYMEVAREKYKERDDRMRGLTDETVDTFYSCVLCQSFAPNHVCIVTPERVGLCGAVSWLDAKASY site                                                       *  *        *         * site                                                      *** 1oaC EINHAGPNQPIPKEGEIDPIKGIWKSVNDYLYTASNRNLEQVCLYTLMENPMTSCGCFEAIMAILPECNGIMITTRDHAGMTPSGMTFST code AB0QBGRG0000R0R0O0QABO00QAAAAAAAAABRRRGR000QG0QG0R000001R0R000000QABRG00000QBGRG00QBRG0QAA LCS  AB0QBGRG0000R0R0 0QAB 00QAAAAAAAAABRRRGR000QG0QG0R000001R0R000000QABRG00000QBGRG00QBRG0QAA code AB0QBGRG0000R0R0R0QAB000QAAAAAAAAABRRRGR000QG0QG0R000001R0R000000QABRG00000QBGRG00QBRG0QAA 1oaD EINHAGPNQPIPKEGEIDPIKGIWKSVNDYLYTASNRNLEQVCLYTLMENPMTSCGCFEAIMAILPECNGIMITTRDHAGMTPSGMTFST site                                                      *** site  1oaC LAG M  IGGGTQTPGFMGIGRTYIVSKKFISADGGIARIVWMPKSLKDFLHDEFVRRSVEEGLGEDFIDKIADETIGTTVDEILPYLEEKGHPALTMDPIM code AAA B  01RR0000RG0000QAAABGQBRRQAB00QABGR000QAAAAAB0AAAAAAAAABRR0QBQAABG00QAB0RGQAA1AAAAAABR0QAABG00-- LCS  AAA B  0   0000RG0000QAAABGQB RQAB00QABGR000QAAAAAB0 AAAAAAAABRR0QBQAABG00QAB0 GQAA1AAAAAABR0QAA G00 code AAAABGO0   0000RG0000QAAABGQB0RQAB00QABGR000QAAAAAB0QAAAAAAAABRR0QBQAABG00QAB00GQAA1AAAAAABR0QAA8G00-- 1oaD LAGMIGGG   TQTPGFMGIGRTYIVSKKFISADGGIARIVWMPKSLKDFLHDEFVRRSVEEGLGEDFIDKIADETIGTTVDEILPYLEEKGHPALTMDPIM site  *RATIO :  lcs/trimmed_seq_a = 0.938 (=  680/  725), lcs/trimmed_seq_b = 0.939 (=  680/  724)

Structural alignment by ComSubstruct + manual inspection

DSSP lLLHHHHHLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHHHHHHHHLLLLLLLLLLLLLLLHHHHHHLLLLLLLHHHHHHHHHHHHHHL 1oaC mTDFDKIFEGAIPEGKEPVALFREVYHGAITATSYAEILLNQAIRTYGPDHPVGYPDTAYYLPVIRCFSGEEVKKLGDLPPILNRKRAQV       ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1oaD .TDFDKIFEGAIPEGKEPVALFREVYHGAITATSYAEILLNQAIRTYGPDHPVGYPDTAYYLPVIRCFSGEEVKKLGDLPPILNRKRAQV DSSP .LLHHHHHLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHHHHHHHHLLLLLLLLLLLLLLLHHHHHHLLLLLLLHHHHHHHHHHHHHHL DSSP LLLLLHHHHHHHHHHHHHHHHHHHHHHHHHLLLLLLLLLLLLLLLLLHHHHHHLHHHHLLLLLLLEEEEEELLLLHHHHHHHHHHHHHLL 1oaC SPVLNFENARLAGEATWYAAEIIEALRYLKYKPDEPLLPPPWTGFIGDPVVRRFGIKMVDWTIPGEAIILGRAKDSKALAKIVKELMGMG      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1oaD SPVLNFENARLAGEATWYAAEIIEALRYLKYKPDEPLLPPPWTGFIGDPVVRRFGIKMVDWTIPGEAIILGRAKDSKALAKIVKELMGMG DSSP LLLLLHHHHHHHHHHHHHHHHHHHHHHHHHLLLLLLLLLLLLLLLLLHHHHHHLHHHHHLLLLLLEEEEEELLLLHHHHHHHHHHHHHLL DSSP LEEEEELHHHHHHHHLLLLLLHHHLEEEEELHHHHHHHHHHHHHHHHLLLLLLLLLHHHHHHHHHHHLLEEEEEELLLLHHHHHHHHHHH 1oaC FMLFICDEAVEQLLEENVKLGIDYIAYPLGNFTQIVHAANYALRAGMMFGGVTPGAREEQRDYQRRRIRAFVLYLGEHDMVKTAAAFGAI      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1oaD FMLFICDEAVEQLLEENVKLGIDYIAYPLGNFTQIVHAANYALRAGMMFGGVTPGAREEQRDYQRRRIRAFVLYLGEHDMVKTAAAFGAI DSSP LEEEEELHHHHHHHHLLLLLLHHHLEEEEELHHHHHHHHHHHHHHHHHLLLLLLLLHHHHHHHHHHHLLEEEEEELLLLHHHHHHHHHHH DSSP HHLLLEEELLLLLHHHLLLLLEEELLLHHHHHHHHHHHHLLLlllllllllllllhhhhhllllhhheeeeeellllleeeeeeellhhh 1oaC FTGFPVITDQPLPEDKQIPDWFFSVEDYDKIVQIAMETRGIKltkikldlpinfgpafegesirkgdmyvemggnrtpafelvrtvsese      |||||||||||||||||||||||||||||||||||||||||| 1oaD FTGFPVITDQPLPEDKQIPDWFFSVEDYDKIVQIAMETRGIKltkikldlpinfgpafegesirkgdmyvemggnrtpafelvrtvsese DSSP HHLLLEEELLLLLHHHLLLLLEEELLLHHHHHHHHHHHHLLLlllllllllllllhhhllllllhhheeeeeellllleeeeeeelllll DSSP llllleeeelllhhhlllleelleeeeeeeelllllhhhhhhhhhhhhhhhhlllleeeeeelleeeeeeehhhhhhllllhhhhhhhhh 1oaC itdgkievigpdidqipegsklplgilvdiygrkmqadfegvlerrihdfinygeglwhtgqrninwlrvskdavakgfrfknygeilva       1oaD itdgkievigpdidqipegsklplgilvdiygrkmqadfegvlerrihdfinygeglwhtgqrninwlrvskdavakgfrfknygeilva DSSP llllleeeelllhhhlllleeeleeeeeeeelllllhhhhhhhhhlhhhhhhlllleeeeeelleeeeeeehhhhhhlllhhhhhhhhhh DSSP hhhhhlllllleeeeeeellhhhhhhhhhhhhhhhhhhhhhhhlllllllleeeeelhhhhlllllleeellllllllllllhhhhhhhh 1oaC kmkeefpaivdrvqvtiftdeakvkeymevarekykerddrmrgltdetvdtfyscvlcqsfapnhvcivtpervglcgavswldakasy       1oaD kmkeefpaivdrvqvtiftdeakvkeymevarekykerddrmrgltdetvdtfyscvlcqsfapnhvcivtpervglcgavswldakasy DSSP hhhhhlllllleeeeeeellhhhhhhhhhhhhhhhhhhhhhhhlllllllleeeeelhhhhlllllleeellllllllllllhhhhhhhh DSSP hhllllllleeellleeelllleehhhhhhhhhhllllllllllllllllllllllllleeeeeehhhleeeeeellllllllllllhhh 1oaC einhagpnqpipkegeidpikgiwksvndylytasnrnleqvclytlmenpmtscgcfeaimailpecngimittrdhagmtpsgmtfst       1oaD einhagpnqpipkegeidpikgiwksvndylytasnrnleqvclytlmenpmtscgcfeaimailpecngimittrdhagmtpsgmtfst DSSP hhllllllleeellleeelllleehhhhhhhhhhllllllllllllllllllllllllleeeeeehhhleeeeeellllllllllllhhh DSSP hhhhhlllllllleeeelhhhhhlllllhhhlhhhheeellhhhhhhhhhhhhhhhhhllllllhhhhlllllllllhhhhhhhhhhhllhhhhlllll 1oaC lagmigggtqtpgfmgigrtyivskkfisadggiarivwmpkslkdflhdefvrrsveeglgedfidkiadetigttvdeilpyleekghpaltmdpim       1oaD lagmigggtqtpgfmgigrtyivskkfisadggiarivwmpkslkdflhdefvrrsveeglgedfidkiadetigttvdeilpyleekghpaltmdpim DSSP hhhhhlllllllleeeelhhhhhlllllhhhlhhhheeellhhhhhhhhhhhhhhhhhllllllhhhhlllllllllhhhhhhhhhhhllhhhhlllll DSSP hlhhhheeellhhhhhhhhhhhhhhhhhllllllhhhhlllllllllhhhhhhhhhhhll 1oaC dggiarivwmpkslkdflhdefvrrsveeglgedfidkiadetigttvdeilpyleekgh       1oaD dggiarivwmpkslkdflhdefvrrsveeglgedfidkiadetigttvdeilpyleekgh DSSP hlhhhheeellhhhhhhhhhhhhhhhhhllllllhhhhlllllllllhhhhhhhhhhhll *Z-score 55.8  AR 311  RMSD 0.6A  SI 100%

Structural alignment by DaliLite

(3) Cluster 43

				Z-Score: 27.1 AR: 148 RMSD: 1.1A SI: 97%
1oc3 A (len 162)	1oc3 C (len 161)		DaliLite result

site                                               + 1ocA SAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTH L   PGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHK code --0000BG000R00000R0QBG000QAAAB0RG0000000R00R00AAGB00 A   AAAAABQAAAAABRRR000000RG0QAAAAAAAAABR LCS     000 G000R00000R0QBG000QAAAB0RG0000000R00R0     00 A   AAAAABQAAAAABR R000000RG0QAAAAAAAAABR code  --000RG000R00000R0QBG000QAAAB0RG0000000R00R03    001ABGQAAAAABQAAAAABR0R000000RG0QAAAAAAAAABR 1ocC  APIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTP    GCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHK site                                                    + site  1ocA AEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGT  G  LTCSLAPNIISQL code R0RG00000RQBRQAAAB0RRG00RQBQB03R000000000000RRG0R00000QBQG  0  00QBGQAAAAA-- LCS  R0RG00000RQBRQAAA 0RRG00RQBQB0 R000000000000RRG0R00000      0  00   Q   AA code R0RG00000RQBRQAAAA0RRG00RQBQB0BR000000000000RRG0R000000RRRRR01R0000 Q   AA-- 1ocC AEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPN I   ISQL site *RATIO :  lcs/trimmed_seq_a = 0.873 (=  138/  158), lcs/trimmed_seq_b = 0.879 (=  138/  157)

Structural alignment by ComSubstruct + manual inspection

DSSP lLLLLLLLLLLLLEEELLLLLLEEEHHHHLLLLEEEEEEELLLLLHHhHHLH.HHHHHHLHHHHHHLLEEEEEEEELLLHHHHHHHHHHLL 1ocA sAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGcSKTH.LPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHK       ||||||||||||||||||||||||||||||||||||||||||||||      |||||||||||||||||||||||||||||||||||||| 1ocC .APIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPG.CSKThLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHK DSSP .LLLLLLLLLLLLEEELLLLLLEEEHHHHLLLLEEEEEELLLLLLLL.LHHHlHHHHHHLHHHHHHLLLLEEEEEELLLHHHHHHHHHHLL DSSP LLLLLEEEELLLLHHHHHHLLLLLLLLHHHHLLLLLLLEEEEEELLEEEEEEELLLLLLLllllhhhhhlll 1ocA AEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLtcslapniisql      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1ocC AEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLtcslapniisql DSSP LLLLLEEEELLLLHHHHHHLLLLLHHHHHHHLLLLLLLEEEEEELLEEEEEEELLLLLLLllllllllhhhl *Z-score 27.1  AR 148  RMSD 1.1A  SI 97%

Structural alignment by DaliLite

(4) Cluster 44

				Z-Score: 15.1 AR: 105 RMSD: 3.8A SI: 91%
1opk A (len 449)	2abl (len 163)		DaliLite result

site  1opk         NLFVALYDFVA  SGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSG  INGSFLVRE code         --000R00000  1RQBG00000R000000000QBRR000000QB000000QABG00QBGQABGQBGR0000QAAAAAAAABG  00R000000 LCS            000R00000  1R  G00000R000000000QBRR00 000Q 000000QABG00   QABGQBG 0000QAAAAAA  B   00R000000 code --00QB0QBG000R00000R01R  G00000R000000000QBRR00R000Q8000000QABG00R00QABGQBG00000QAAAAAA  BR0000R000000 2abl MGPSENDPNLFVALYDFVASGDN  TLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL  LSSGINGSFLVRE site site                                                       *********              * 1opk SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDIT code 0QB00RG0000000RRG000000000QBR000RGQBG00R0QAAAAAAAAG0RRRGR00300000R0G0000R00GRG00RRG00Q---- LCS  0Q 0  G0000000RRG000000000QBR000RG  G00R0QAAAAAAAA 0RRRGR00 0000 code 0QG0QAG0000000RRG000000000QBR000RGPAG00R0QAAAAAAAAB0RRRGR00 0000-- 2abl SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITT LHYPAP site site    ++++++++++++++++++++++++                                                    * 1opk MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQ code ------------------------------------------------------------------------------------------ LCS  code  2abl site site  1opk EVSAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW code ------------------------------------------------------------------------------------------ LCS  code  2abl site site  1opk AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK code ------------------------------------------------------------------------------------------ LCS  code  2abl site *RATIO :  lcs/trimmed_seq_a = 0.770 (=  134/  174), lcs/trimmed_seq_b = 0.843 (=  134/  159)

Structural alignment by ComSubstruct + manual inspection

DSSP ..LEEEelllllllllllllllllleeeeeeelllLLEEE.............................eelllleeeeehhheeellLHHHLLLEEEELLHHHHHHHHHHLLLLEEEEEE 1opk ..NLFValydfvasgdntlsitkgeklrvlgynhnGEWCE.............................aqtkngqgwvpsnyitpvnSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRE                                                                                              ||||||||||||||||||||||||||||||||| 2abl mgPSEN.......................dpnlfvALYDFvasgdntlsitkgeklrvlgynhngewceaqtkngqgwvpsnyitpvnSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRE DSSP llLLLL.......................llleeeELLLLlllllllllllllleeeeeeellllleeeeeelleeeeeehhheeellLHHHLLLEEEELLHHHHHHHLLLLLLLLEEEEE DSSP LLLLLLLEEEEEEELLEEEEEELEELLLLLEELLLLLLLLLHHHHHHHHLLLLLLLLLLLLEEllllllllllllllllllllllhhhee 1opk SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPapkrnkptiygvspnydkwemertdit      ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 2abl SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP........................... DSSP LLLLLLLEEEEEEELLEEEEEEEEELLLLLEELLLLLEELLHHHHHHHHHHLLLLLLLLLLLL........................... DSSP eeeelhhhlllleeeeeehhhleeeeeeelllllllhhhhhhhhhhhhhlllllllleeeeelllllleeeeellllllhhhhhhhllll 1opk mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrq       2abl .......................................................................................... DSSP .......................................................................................... DSSP lllhhhhhhhhhhhhhhhhhhhhlleelllllhhheeelhhhleeellllleelllllleellllllllhhhllhhhhhhleelhhhhhh 1opk evsavvllymatqissameylekknfihrnlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvw       2abl .......................................................................................... DSSP .......................................................................................... DSSP hhhhhhhhhhlllllllllllhhhhhhhhhllllllllllllhhhhhhhhhhllllhhhlllhhhhhhhhhlllllllhhhhhhhhhhl 1opk afgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgk       2abl .......................................................................................... DSSP .......................................................................................... *Z-score 15.1  AR 105  RMSD 3.8A  SI 91%

Structural alignment by DaliLite

(5) Cluster 45

				Z-Score: 31.6 AR: 273 RMSD: 0.9A SI: 100%
1qex A (len 288)	1s2e A (len 288)		DaliLite result

site  1qex MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTS code --00000000RQBHQBGRGQAAAAAAAAAAAAAAAAAAAAABG0QAAABGRRRG0QB00000QB0000000QAAABG0000R000R00RQ LCS    00000000RQBH     QAAAAAAAAAAAAAAAAAAAAABG0QAAABGRRRG0QB00000QB0000000QAAABG0000R000R00RQ code --00000000RQBH1A800QAAAAAAAAAAAAAAAAAAAAABG0QAAABGRRRG0QB00000QB0000000QAAABG0000R000R00RQ 1s2e MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTS site site  1qex TVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWN code B000000000000R0000000QBRRG0QAB0000000R000RG000000O00R0000000R0000RR000000000R000000R000000 LCS  B000000000000R0000000QBRRG0QAB0000000R000RG000000O00R0000000R0000RR000000000R000000R000000 code B000000000000R0000000QBRRG0QAB0000000R000RG000000O00R0000000R0000RR000000000R000000R000000 1s2e TVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWN site site  1qex ISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ code R0QBRG0000000QAB0R0000000000QBRRG0000000000RQABRG000001R0000R0R0RG30R00000000RRGR000000RG0R0000000R0000000-- LCS  R0QBRG0000000QAB0R0000000000QBRRG0000000000RQABRG000001R0000R0R0RG30R00000000RRGR000000RG0R0000000R0000000 code R0QBRG0000000QAB0R0000000000QBRRG0000000000RQABRG000001R0000R0R0RG30R00000000RRGR000000RG0R0000000R0000000-- 1s2e ISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ site *RATIO :  lcs/trimmed_seq_a = 0.982 (=  279/  284), lcs/trimmed_seq_b = 0.982 (=  279/  284)

Structural alignment by ComSubstruct + manual inspection

DSSP lllllllllllllllLLLLHHHHHHHHHHHHHHHHHHHHLLLLLHHHHHLLLLLLLLLLLLLLLLLLLLLLLLHHHLLLLLLLEEELLLL 1qex mfiqepkklidtgeiGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTS                     ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1s2e mfiqepkklidtgeiGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTS DSSP lllllllllllllllLLLLLHHHHHHHHHHHHHHHHHHHLLLLLHHHHHLLLLLLLLLLLLLLLLLLLLLLLLHHHLLLLLLLEEELLLL DSSP LLLEEEEELLLLLLLEEEEELLLLLLLLLLLEEEEELLEELLLLLLEEELLLLEEEEEEEEELLLLLLEEEEEEEELLLLLLLLLEEEEE 1qex TVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWN      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1s2e TVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWN DSSP LLLEEEEELLLLLLLEEEEELLLLLLLLLLLEEEEELLEELLLLLLEEELLLLEEEEEEEEELLLLLLEEEEEEEELLLLLLLLLEEEEE DSSP LLLLLEEEEEEEELLLLLEEEEEEEEEELLLLLEEEEEEEEEEELLLLEEEEEEEEEEELLLLLLLLLLLEEEEEEELLEEEEEEELLLLLEEEEEEEEEEELLLLLL 1qex ISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1s2e ISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ DSSP LLLLLEEEEEEEELLLLLEEEEEEEEEELLLLLEEEEEEEEEEELLLLEEEEEEEEEEELLLLLLLLLLLEEEEEEELLEEEEEEELLLLLEEEEEEEEEEELLLLLL *Z-score 31.6  AR 273  RMSD 0.9A  SI 100%

Structural alignment by DaliLite

[The DSSP code]

• H = alpha helix
• B = residue in isolated beta-bridge
• E = extended strand, participates in beta ladder
• G = 3-helix (3/10 helix)
• I = 5 helix (pi helix)
• T = hydrogen bonded turn
• S = bend
• L = no assigned structure

[The 5-tile code]

• 0 = DDDDD    (extended strand, small blue spheres)
• 1 = DDDDU
• 2 = DDDUD
• 3 = DDDUU
• 8 = DUDDD
• 9 = DUDDU
• A = DUDUD    (helix, large red spheres)
• B = DUDUU    (turn, large yellow spheres)
• G = UDDDD
• H = UDDDU
• I = UDDUD
• J = UDDUU
• O = UUDDD
• P = UUDDU
• Q = UUDUD    (turn, large yellow spheres)
• R = UUDUU    (turn, large yellow spheres)