• #lenN stands for the number of occurrence of variable regions of length N.
• Backbone structures are obtained using ProteinViewer, where N-terminal is colored red and C-terminal blue.
• In the images, the CA atoms of the variable regions are drawn as large blue sphere.
  
• The "site" row indicates active site residues:
          "*" denotes active sites registered in SwissProt/UniProt.
          "+" denotes active sites registered in PROSITE/UniProt.
           Residues registered in both of them are denoted by "*."
• Click the images to view larger image.
• See the bottom for brief explanation of the DSSP codes and the 5-tile codes. 
• "*" indicates the region of left- or right-handed helical structure.

(1) Cluster 56: #len7 = 1, #len2 = 2

				Z-Score: 2.3 AR: 39 RMSD: 6.4A SI: 74%
2beq D (len 46)	2beq F (len 46)		DaliLite result

site  2beD --RHQBG000000RQAAAAAAAAAAAJQAABGR0QAAAAAAAAA-- Res  LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 2beF --0RQBG000000RQAAAAAAAAAAAB0RRG000QAAAABQAAA--

5-tile code sequences

DSSP LLLLLLLLLLLLLLHHHHHHHHHHHLLHhHHLLlhhhhhHHHHHHL...... 2beD LGDISGINASVVNIQKEIDRLNEVAKNLnESLIdlqelgKYEQYIK......      ||||||||||||||||||||||||||||                 | 2beF LGDISGINASVVNIQKEIDRLNEVAKNL.NESL.....iDLQELGKyeqyik DSSP LLLLLLLLLLLLLLHHHHHHHHHHHHLL.LLLL.....lLHHHHLLhhhhhl

Structural alignment by DaliLite

(2) Cluster 10: #len7 = 1, #len4 = 2, #len3 = 1, #len2 = 1, #len1 = 1

			No Significant Similarity	Z-Score: - AR: - RMSD: - A SI: - %
1d2z C res78-129 (len 52)	1ik7 A (len 52)		DaliLite result

site  1d2z --00QAAAAAAGAAB8BR00QAAAAAAAAABRRQAAAAABQABG0QAAAA-- Res  RGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYI 1ik7 --AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--

5-tile code sequences

DSSP  1d2z       1ik7 DSSP

Structural alignment by DaliLite

(3) Cluster 39: #len7 = 1, #len6 = 1, #len4 = 1, #len1 = 2

				Z-Score: 4.8 AR: 60 RMSD: 2.2A SI: 95%
1mi7 R (len 103)	1p6z R (len 102)		DaliLite result

site  1mi7 --0QIAAAAAAAAAAAAAAAAAAAAAAAAGRRQAAAAAAB00QAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAABG0QAAAAAAAAA-- Res  QQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLL 1p6z  --R00QAAAAAAAAAAAAAAAAAAAAAABRRQAAAAAABG0QAAAAAAAAAAAAAAAAABRGG0QAAAAB0RR00QAAAAAAAAAAABG0QAAAAAAAAA--

5-tile code sequences

DSSP LLLHhHHHHHHHHHHHHHHHHHHHHHHHLLLLHHHHHHHHLLHHHHHHHHHHHHHHHHHHHhhhhhhhhhhhhhhhhhhhhhhhhhhhhllhhhhhhhhhhhl 1mi7 QQSPySAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRgemsqrelknelgagiatitrgsnslkaapvelrqwleevll      |    |||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1p6z QSPY.SAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRgemsqrelknelgagiatitrgsnslkaapvelrqwleevll DSSP LLLL.LHHHHHHHHHHHHHHHHHHHHHHHHLLHHHHHHHHLLHHHHHHHHHHHHHHHHHHHllllhhhhhhhhlllhhhhhhhhhhhhhllhhhhhhhhhhhl

Structural alignment by DaliLite

(4) Cluster 31: #len8 = 1, #len3 = 1, #len2 = 1, #len1 = 1 (, #len9 = 1)

				Z-Score: 3.7 AR: 65 RMSD: 5.5A SI: 57%
2ou1 A (len 72)	1l6l 6 (len 75)		DaliLite result

site  2ou1   --RQAAAAAAAAAAAAAAAAAAAAAAAGQB01R1AAAAAGAAAAAAAAAAAAAABGQA---AAAAAAG1AA--- Res  AKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPAQT 1l6l --00RHQAAABHQAAAAAAAAAAAAAAABHRGR0QAAAAAAAAAAAAAAAAAAAAABGQAAAAAG10000000--

5-tile code sequences

DSSP ....LLLL.HHHHhHHHHHHHHHHhHHHHHHHHhHLLLLLLHHHHHHHLLLLHHHHLHHHHLLL.LHHHHhhHHLL..ll 2ou1 ....EPCV.ESLVsQYFQTVTDYGkDLMEKVKSpELQAEAKSYFEKSKEQLTPLIKKAGTELVN.LSYFVelGTQP..at                |       |               |||||||||||||||||||||||||||||| ||||| 1l6l akepCVESlVSQY.FQTVTDYGKD.LMEKVKSP.ELQAEAKSYFEKSKEQLTPLIKKAGTELVNfLSYFV..ELGTqpaq DSSP llllLLHHhHLLH.HHHHHHLLHH.HHHHHLLL.LLLHHHHHHHHHHHHHHHHHHHHHHLLHHHhHLLLL..LLLLllll

Structural alignment by DaliLite

(5) Cluster 32: #len11 = 1, #len6 = 1, #len3 = 1, #len2 = 1, #len1 = 1

				Z-Score: 4.1 AR: 66 RMSD: 7.7A SI: 53%
2ou1 B (len 71)	1l6l 2 (len 73)		DaliLite result

site  2ou1 --RHRAAAAA-AAAAAAAAAAAAAAAAAB00RGQAAAAAAAAAAAAAAAAAAAAG1AAAAAAAAAAB1AA-- Res  EPCVSLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ 1l6l --0PAAAAAAAAAAAAAAAAAAAAHB1QAAG0QBQAAAAAAAAA1AAAAAAAAAHQAAAAAAAAGG00000--

5-tile code sequences

DSSP LLLL.LHHHHL.LHHHHHHHHHHHHHHLLLLLLlHHHHHHHLLLLHHHHHHLHHHHHHHHHHHHHhhHHLL...ll 2ou1 EPCV.SLVSQY.QTVTDYGKDLMEKVKSPELQAeAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVelGTQP...at      ||||                              ||||||||||||||||||||||||||||||| 1l6l EPCVsLVSQYFqTVTDYGKDLMEKVKSPELQAE.AKSYFEKSKEQLTPLIKKAGTELVNFLSYFV..ELGTqpatq DSSP LLLLlLHHHHHhHHHHHHHHHHHLLLLHHHHLL.LHHHHHHHHHHHHHHHHHLHHHHHHHHHHHL..LLLLlllll

Structural alignment by DaliLite

(6) Cluster 52: #len11 = 1, #len6 = 1, #len3 = 1, #len1 = 4

				Z-Score: 13.2 AR: 91 RMSD: 3.4A SI: 90%
1vr4 A (len 103)	1vr4 D (len 103)		DaliLite result

site  1vrA --00RGR000RG00R0000000000000QAAAAABRQBRG0000QB0RGR00QAQAAAAAAAAAAAAAAAABR0R000R000000000R000000000000-- Res  MIVTTTSGIQGKEIIEYIDIVNGEAIMGANIVRDLFASVRDVVGGRAGSYESKLKEARDIAMDEMKELAKQKGANAIVGVDVDYEVVRDGMLMVAVSGTAVRI 1vrD --00RGR000RG00R0R0000000000000R00RG000QG0G0R00000QAAAAAAAAAAAAAAAAAAAAABR0R000R000000000RR00000000000--

5-tile code sequences

DSSP LEELLLLLLLLLLLLEEEEEEEEEEEELhhhHHLLLH......hhlllLLLLllllLLLLHHHHHHHHHHHHHHHHHLLLLEEEEEEEEEEEEHHHEEEEEEEEEEEEL 1vrA MIVTTTSGIQGKEIIEYIDIVNGEAIMGaniVRDLFA......svrdvVGGRagsyESKLKEARDIAMDEMKELAKQKGANAIVGVDVDYEVVRDGMLMVAVSGTAVRI      ||||||||||||||||||||||||||||                      |     ||||||||||||||||||||||||||||||||||||||||||||||||||||| 1vrD MIVTTTSGIQGKEIIEYIDIVNGEAIMG...ANIVRDlfasvrdvvggRAGS...yESKLKEARDIAMDEMKELAKQKGANAIVGVDVDYEVVRDGMLMVAVSGTAVRI DSSP LEELLLLLLLLLLLLEEEEEEEEEEELL...LEEELLeelllllllllLLLL...hHHHHHHHHHHHHHHHHHHHHHLLLLEEEEEEEEEEEEHHHEEEEEEEEEEEEL

Structural alignment by DaliLite

(7) Cluster 17: #len12 = 1, #len8 = 1, #len3 = 2, #len2 = 3, #len1 = 4

			NA	Z-Score: 26.9 AR: 199 RMSD: 2.0A SI: 96%
1fm6 A (len 232)	1g1u A (len 229)		DaliLite result

site  1fm6 --R00QAAAAAAAAB00000QABHQ00000000R00G2AAAAAAAAAAAAAAAAAAAABG0RQABG0QAAAAAAAAB1QAAAAAAAAAAA Res  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHR 1g1u     --AAAAAAAAB0000QAAAB01RRQBBGR00000QAAAAAAAAAAAAAAAAAAABG0RQABG0QAAAAAAAAB1QAAAAAAAAAAA site 1fm6 AQBG000000QBR00001AAAAABRR0QAAAAAA0B0QAAAAABR00QAAAAAAAAAAAB0QB00R0R0QAAAAAAAAAAAAAAAAAAAA Res  SIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKH 1g1u AQBG0G0000QBR0000QAAAAABRRQAAAAAAA0B0QAAAAABR00QAAAAAAAAAAAB0QBG0R0R0QAAAAAAAAAAAAAAAAAAAA site 1fm6 B0QBGQBQAAAAAAAAAAAAAAAAAAAAAAAAAABB00R0001QAAAABR-- Res  KYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPH 1g1u B0QAGQBQAAAAAAAAAAAAAAAAAAAABRQAAABB1QAAAAAAAAAAABG--

5-tile code sequences

DSSP llllLHHHHHHHHHLLLLLLLHHHH.lllLLLLLLLllllhhhhHHHHHHHHHHHHHHHHLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHH 1fm6 nedmPVERILEAELAVEPKTETYVE.anmGLNPSSPndpvtnicQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHR          |||||||||||||||||||||        |          ||||||||||||||||||||||||||||||||||||||||||||||| 1g1u ....PVERILEAELAVEPKTETYVEanmgLNPSSPN.dpvtnicQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHR DSSP ....LHHHHHHHHHHLLLLLLLLLLllllLLLLLLL.lhhhhhhHHHHHHHHHHHHHHLLLLLHHHLLHHHHHHHHHHHHHHHHHHHHHHH DSSP LLLLLLEEELLLLLEEEHHHHHLLLLLLHHHHHHHHLHHHHHHLLLLHHHHHHHHHHHHLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHH 1fm6 SIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKH      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1g1u SIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKH DSSP HHHLLLLEELLLLLEELHHHHHHLLLHHHHHHHHHHLHHHHHHHLLLHHHHHHHHHHHHLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHH DSSP HLLLLLLHHHHHHLLHHHHHHHHHHHHHHH....hhhhllLLLLllllhhhhllll 1fm6 KYPEQPGRFAKLLLRLPALRSIGLKCLEHL....fffkliGDTPidtflmemleap      ||||||||||||||||||||||||||||||           || 1g1u KYPEQPGRFAKLLLRLPALRSIGLKCLEHLfffkligdtpIDTF...lmemleaph DSSP HLLLLLLHHHHHHLLHHHHHHHHHHHHHLLhhhhhhhhhhHHHH...hhhhhhlll

Structural alignment by DaliLite

(8) Cluster 1: #len17 = 1, #len7 = 1, #len3 = 2, #len2 = 3, #len1 = 16

				Z-Score: 20.2 AR: 152 RMSD: 2.3A SI: 97%
1a1q A (len 183)	1jxp A (len 177)		DaliLite result

site                                                       *                       * 1a1q --000000RG0G0000000QR10R1R0000RG00000QG000000000RG0000PGRGRGR0000QB000000000QBRRG0000000R000 Res  PITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARS 1jxp  --00000R00QAAAAAAAABRG0RG0000OG00000R000000000RRG0000QAB00R00000R000000R000QABRG0003000R000 site   * *                                       *     *   * 1a1q 00001RR0RG00000QBR000000000R0G000R0000QAABGRR0R00000QBR00R000000000RRG00000000QAAB0QABG00-- Res  LTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRSPVF 1jxp 0000RRR0RG00000QBR0R00000R0RRG000Q8R00QAAB0RR1RG0000QBR00000R000R00R0G0R000000QAAAAA--

5-tile code sequences

DSSP llllllllllllllllllllllllLLLLLLLEEEEEELLEEEEEEELLLEEEEELLLLLLllLEELL..EELLLLEELLLLLEEEEELLLLLLL 1a1q pitaysqqtrgllgciitsltgrdKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSktLAGPK..GPITQMYTNVDQDLVGWQAPPGARS                              ||||||||||||||||||||||||||||||||||||         ||||||||||||||||||||||||| 1jxp .itaysqqtrgllgciitsltgrdKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGS..KTLAGpkGPITQMYTNVDQDLVGWQAPPGARS DSSP .llllllllllhhhhhhhhhllllLLLLLLLEEEEELLLLEEEEEEELLEEEEEHHHHLL..LLEEEllEEELLLEEELLLLEEEEELLLLLLL DSSP LLLLLLLLLEEEELLLLLLLEEEEEEELLEEEEEEEELHHHHLLLLLLEEELLLLLEEEEEEEEELLLLLEEEEEEEELLLLLLLLleell 1a1q LTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMrspvf      |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 1jxp LTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTM..... DSSP LLLLLLLLLEEEEELLLLLEEEEEELLLLEEEEEEEEEHHHHLLLLLLEEEELLLEEEEEEEEEEEELLEEEEEEEEEHHHHHLLL.....

Structural alignment by DaliLite

[The DSSP code]

• H = alpha helix
• B = residue in isolated beta-bridge
• E = extended strand, participates in beta ladder
• G = 3-helix (3/10 helix)
• I = 5 helix (pi helix)
• T = hydrogen bonded turn
• S = bend
• L = no assigned structure

[The 5-tile code]

• 0 = DDDDD    (extended strand, small blue spheres)
• 1 = DDDDU
• 2 = DDDUD
• 3 = DDDUU
• 8 = DUDDD
• 9 = DUDDU
• A = DUDUD    (helix, large red spheres)
• B = DUDUU    (C-cap, large orange spheres)
• G = UDDDD
• H = UDDDU
• I = UDDUD
• J = UDDUU
• O = UUDDD
• P = UUDDU
• Q = UUDUD    (N-cap, large orange spheres)
• R = UUDUU    (turn, large yellow spheres)