• Backbone structures are obtained using ProteinViewer, where N-terminal is colored red and C-terminal blue.
• Click the images to view larger image.
• Click PDB IDs to view the corresponding PDB file
• See the bottom for explanation of the DSSP codes and the 5-tile codes. 
• "<" and ">" denote the N-terminal and the C-terminal of the sequence respectively.
  

(1) Synaptotagmin C2 Domain (1rsy) and Phospholipase C C2 Domain (1qas)

			"The first beta-strand in 1rsy corresponds to the last beta-strand in 1qas and the topologies of the two domains are related by a circular permutation." (Grishin, 2001)
1rsy (Res142-262)	1qas (Res629-756)

1rsy   <KLQYSLDYDFQNN   QLLVGIIQAAELPALDMGGTSDP YVKVFLLPDK  K  KKFETKVHRKTLN code   <000000000QABR   00000R0000R000RGQBRG0R0 0000000O0R  Q  G00000000R0QG LCS     000000000   R   00000R0000R000      0 0 0000000 0   Q  G00000000 0 G code R00000000000   R><300000R0000R000      0O010000000 0000QABG00000000 0RG 1qas PSATLFVKISIQ   D><ERLRVRIISGQQLPK      VNIVDPKVIVE IHGVGRDTGSRQTAVI TNN 1rsy     PVFNEQFTFKVP  YSELGGKTLVMAVYDFDRFSKHDIIGEFKVP MNTVDFGHVTEEWR> code     00OR00000R00  QAAAABG0000000000R000000R000000 QABG01RG000000> LCS      00 R00000 00  QA   BG0000000000R000000 000000 QABG0   000000 code QB0000 R00000 00R0QA   BG0000000000R000000 0000000QABG0   0000000000QB 1qas GFNPRW DMEFEF EVTVPD   LALVRFMVEDYDSSSKNDF IGQSTIPWNSLK   QGYRHVHLLSKN *RATIO :  lcs/trimmed_seq_a = 0.803 (=   94/  117), lcs/trimmed_seq_b = 0.790 (=   94/  119)

Structural alignment by ComSubstruct

DSSP <...LLEEEEEEEEELll  LEEEEEEEEEELLLLLLlllLLLEEEEEEEEL..llLLLEELLLLLLLL.L 1rsy <...LGKLQYSLDYDFqn  NQLLVGIIQAAELPALDmggTSDPYVKVFLLP..dkKKKFETKVHRKTL.N             |              | | ||    ||        || | |             | |      | 1qas  qhpSATLFVKISIQD..><ERLRVRIISGQQLPKVN...IVDPKVIVEIHGvgrdTGSRQTAVITNNGfN DSSP  lllLLEEEEEEEEEL..><LEEEEEEEEEELLLLLL...LLLEEEEEEEELllllLEEEELLLLLLLLlL DSSP LEEEEEEEELLLhhHHLLLEEEEEEEELLLLLLLEEEEEEEEEHHHLLlllLEEEEEEL......> 1rsy PVFNEQFTFKVPysELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDfghVTEEWRDL......>      |     | | |             | | |  || | ||    | |             | 1qas PRWDMEFEFEVT..VPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLK...QGYRHVHLlskngd DSSP LEEEEEEEEELL..LHHHLEEEEEEEELLLLLLLEEEEEEEEEHHHLL...LEEEEEELllllll *Z-score 15.6  AR 109  RMSD 1.8A  SI 27%

Structural alignment by DaliLite

(2) NK-lysin (1nkl) and Saposin (1qdm)

			"About half of the domain chain participates in this permutation event. Permutation in saposins has been detected by the sequence analysis before either structure became available, which leaves no doubt about homology between 1nkl and 1qdm." (Grishin, 2001)
1nkl (Res1-78)	1qdm (ResA2S-102S)

1nkl    <FCESCRKIIQKLEDMVGPQPNEDTVTQAASQVCDKL    KILRGLCKKIMRSF L RRISWDILTGKKPQA ICVDIKIC> code    <AAAAAAAAAAAAAAIB00R00QAAAAAAAAAAAAAB    0QBQAAAAAAAAB0 1 AAAAAAAABR00QAA AAAAB0OG> LCS      AAAAAAAAAAAAAA B  R00QAAAAAAAAAAA  B    0Q  AAAAAA   0 1 AAAAAAAABR00QAA AAA B0 code AAAAAAAAAAAAAAAAAA B  R00QAAAAAAAAAAA  BO><30Q  AAAAAA   0B1QAAAAAAAABR00QAAHAAA B0 1qdm PMCSACEMAVVWMQNQLA Q  NKTQDLILDYVNQLC  NR><VSQ  ECKTIV   SQYGQQILDLLLAETQPKKICSQ VG *RATIO :  lcs/trimmed_seq_a = 0.824 (=   61/   74), lcs/trimmed_seq_b = 0.871 (=   61/   70)

Structural alignment by ComSubstruct

DSSP <.LLHHHHHHHHHHHHHHHHLLLLLHHHHHHHHHHHHHHlll  lHHHHHHHHHHHHHHHHHHHHLLLLHHHHHHHLLLLll> 1npx <.GYFCESCRKIIQKLEDMVGPQPNEDTVTQAASQVCDKlki  lRGLCKKIMRSFLRRISWDILTGKKPQAICVDIKICke>           |  |                 |       | |           || |       |    |    |  ||     | 1ldn  aDPMCSACEMAVVWMQNQLAQNKTQDLILDYVNQLCNR...><vSQECKTIVSQYGQQILDLLLAETQPKKICSQVGLC.. DSSP  lHHHHHHHHHHHHHHHHHHHLLLLHHHHHHHHHHHLLL...><lLHHHHHHHHHLHHHHHHHHHLLLLHHHHHHHLLLL.. *Z-score 8.5  AR 72  RMSD 2.4A  SI 19%

Structural alignment by DaliLite

[The DSSP code]

• H = alpha helix
• B = residue in isolated beta-bridge
• E = extended strand, participates in beta ladder
• G = 3-helix (3/10 helix)
• I = 5 helix (pi helix)
• T = hydrogen bonded turn
• S = bend
• L = no assigned structure

[The 5-tile code]

• 0 = DDDDD    (extended strand, small blue spheres)
• 1 = DDDDU
• 2 = DDDUD
• 3 = DDDUU
• 8 = DUDDD
• 9 = DUDDU
• A = DUDUD    (helix, large red spheres)
• B = DUDUU    (turn, large yellow spheres)
• G = UDDDD
• H = UDDDU
• I = UDDUD
• J = UDDUU
• O = UUDDD
• P = UUDDU
• Q = UUDUD    (turn, large yellow spheres)
• R = UUDUU    (turn, large yellow spheres)