"A large superfamily of S-adenosylmethionine-dependant methyltransferases is characterized by two highly conserved motifs that map to the C-termini of beta-strands a and d. It has been noticed that methyltransferase subfamilies differ in the sequence order of these motifs, suggesting a circular permutation." (Grishin, 2001) | |||
1aqi (ResA21-222) | 1boo
(Res22-318) |
1aqi
<TPPEVVDFMVSLAEAPRGGRVLE
PACAHGPFLRAFREAHGTGYRFVGVEIDPK
ALDLPPWAE
GIL code <00QAAAAAAAABG0000R00000 0R0RR0QAAAAAAA800RRG000000RGQA BG000QBG0 000 LCS 0QAAAAAAAA G0000R00000 0R QAAAAAAA 00 000000RGQA BG QBG0 000 code 0QAAAAAAAA G0000R00000QB30R R QAAAAAAAB00 000000RGQAAAAAAAAABG0 QBG0QAABO><3000 1boo PAKLPEFFIR MLTEPDDLVVDIFGGS N TTGLVAERESR KWISFEMKPEYVAASAFRFLD NNISEEKIT><AYTT 1aqi AD F LL WEPGE AFDLILGNPP YGI VK AVKDLYKK AF ST WKGK YN LYGAFLEKAVRLLKPGGVL VFV code GR Q AB 00RRG 00R0000000 000 00 QAAAAAAA BG QB 000R 00 QAAAAAAAAAABG00R000 000 LCS R Q AB 00R G 00 0000000 000 00 QAAAAAAA BG QB 000R 00 QAAAAAAAAA 00R000 000 code R00000000QAAAAABG00R GGR00 0000000R000G00RR0QAAAAAAAAAAAAAAAAABG0QBG000000000000RGRG00RQAAAAAAAAA 00R000RR000 1boo SNGSMYIGDSLELLESFPEE SISLV MTSPPFALQRKKEYGNLEQHEYVDWFLSFAKVVNKKLKPDGSFVVDFGGAYMKGVPARSIYNFRVLIRMI DEVGFFLAEDF 1aqi VPATWLVLED F ALLREFLAREG K TSVYYLG EVFPQKKVSAVV I RFQKSGKGL S LWDT> code 00RQAB00QA B QAAAAAAA1B0 0 00000R0 RRGQG1RG0000 0 000RG0000 0 0000> LCS 00 00Q B Q A B0 0 0000 R0 R RG0000 0 000RG0000 0 0000 code 00 00QG0QBR0Q A B0R0RR0000 R000000000R0 RG0000QAAB0RR000RG000031RG00QAAAAAAABR0000 1boo YW FNPSKLPSPI E WVNKRKIRVK DAVNTVWWFSKT EWPKSDITKVLASIPPNLLQISNSESNGQYLANCKLMGIKAH *RATIO : lcs/trimmed_seq_a = 0.813 (= 152/ 187), lcs/trimmed_seq_b = 0.596 (= 152/ 255) |
Structural alignment by ComSubstruct |
DSSP <lLLLHHHHHHHHLLlLLLLLLEEEEELLLLLHHHHHHHHHHlllLEEEEEELLLLLLL.................
.LLLL.EEEEE 1aqi <vETPPEVVDFMVSLaEAPRGGRVLEPACAHGPFLRAFREAHgtgYRFVGVEIDPKALD................. .LPPW.AEGIL | | | | | 1boo .RFPAKLPEFFIRM.LTEPDDLVVDIFGGSNTTGLVAERES...RKWISFEMKPEYVAasafrfldnniseekit><aYTTSnGSMYI DSSP .LLLLHHHHHHHHH.HLLLLLEEEELLLLLLHHHHHHHHLL...LEEEEEELLHHHHHhhhhhhllllllhhhhl><lEELLlEEEEE DSSP LLHHHL.LLLL..LEEEEEELLLLLLLllHHHHhhhhllllLLLLL.HHHHHHHHHHHLEEEEEEEEEE 1aqi ADFLLW.EPGE..AFDLILGNPPYGIVkaVKDLykkafstwKGKYN.LYGAFLEKAVRLLKPGGVLVFV | | | | || | | | ||| | | 1boo GDSLELlESFPeeSISLVMTSPPFALQ.rKKEY....gnleQHEYVdWFLSFAKVVNKKLKPDGSFVVD DSSP LLHHHHhHHLLllLEEEEEELLLLLLL.lLLLL....lllhHHHHHhHHHHHHHHHHHHEEEEEEEEEE DSSP EELH.....hhLLHHHHHHHHHHHH..HLEE.EEEEEELllLLLL...............LLEEEEEEELLL..........lle 1aqi VPAT.....wlVLEDFALLREFLAR..EGKT.SVYYLGEvfPQKK...............VSAVVIRFQKSG..........kgl | | | | 1boo FGGAymkgvpaRSIYNFRVLIRMIDevGFFLaEDFYWFN.pSKLPspiewvnkrkirvkdAVNTVWWFSKTEwpksditkvlasi DSSP ELLLeelleeeELLHHHHHHHHHHHllLLEEeEEEEEEL.lLLLLlllhhhhhlllllllLEEEEEEEELLLlllllhhhlllll DSSP eeELLLL.......................> 1aqi slWDTQE.......................> | 1boo ppNLLQIsnsesngqylancklmgikahpa DSSP llLEEELllllllhhhhhhhhhllllllll *Z-score 12.2 AR 167 RMSD 3.4A SI 14% |
Structural alignment by DaliLite |
"1vhr is characterized by a unique topology, which can, however, be converted to 1phr by deletions/insertions and a circular permutation. The conversion results in a superposition of the active sites and produces sequence alignment with 20% identity." (Grishin, 2001) | |||
1phr (Res4-157) | 1vhr
(ResA8-179) |
1phr
<KSVLFVCLG NICRSPIAEAVFRKLVTDQ NI
S
DNWVIDSGAVSDWNVGRSPDPRAVSCLRN
H GINTAHKAR Q VTKE code <00000000R RG01QAAAAAAAAAAAAAB RR Q ABG000000RGRQ80RG000QAAAAAAAA B R000R0000 0 00QA LCS 000000R RG0 AAAAAAAAAAB RR Q AB 000000 Q AAAAAAAA B R000 0000 0 0 code BG000000R0RG00 AAAAAAAAAAB0RR00QAAAAAAAAAB 000000 Q AAAAAAAAAAAAABP><JQAAAAAABGR000G0000R0R0 1vhr NGRVLVHCREGYSR SPTLVIAYLMMRQKMDVKSALSIVRQN REIGPN D GFLAQLCQLNDRLAK><SVQDLNDLLSDGSGCYSLPSQPC 1phr DFVTFD YI LCMDESNL RDLNRKSNQVKNCR AK I ELLGSYDPQK QLIIEDP YYGNDAD FETVYQQCVRCCRAFLEK> code AAA0GR 00 0000QAAA AAAAAAAABG1R0R G0 0 00QAAB0QBR RRGR00R QBG0QAA AAAAAAAAAAAAAAAAAA> LCS 0 R 00 0000QAAA AAAAA B R0R G0 0 00QAAB0QBR R 00R QBG QAA AAAAAAAAAA code 0 RR00RG0000QAAABBQAAAAA B R0R0000QG000GQBG0R00QAAB0QBR000000R 00R0QBGRQAABQAAAAAAAAAA 1vhr N EVTPRIYVGNASVAQDIPKLQK L GITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIK ANDTQEFNLSAYFERAADFIDQA *RATIO : lcs/trimmed_seq_a = 0.707 (= 106/ 150), lcs/trimmed_seq_b = 0.631 (= 106/ 168) |
Structural alignment by ComSubstruct |
DSSP <.LLEEEEEEELLLLLHHHHHHHHHHHHHHHlllhhheeeeeeelllllLLLLLLHHHHHHHHLLL.....
.............................lllllllllLLLL 1phr <.VTKSVLFVCLGNICRSPIAEAVFRKLVTDqnisdnwvidsgavsdwnVGRSPDPRAVSCLRNHG..... .............................intahkarqVTKE || | ||| | | 1vhr qKNGRVLVHCREGYSRSPTLVIAYLMMRQK.....mdvksalsivrqnREIGPNDGFLAQLCQLNdrlak><svqdlndllsdgsgcyslpsqpcnevtpriyvgnasvaQDIP DSSP lLLLLEEEELLLLLLHHHHHHHHHHHHHLL.....llhhhhhhhhhhhLLLLLLHHHHHHHHHHHhhhhl><lhhhhhhhhllllllllllllleeeeelleeeelhhhhLLHH DSSP HHH..HLLEEEELLHH....HHHHHHHHHHlllLLLLEEEEhhhhllllllLLLLLllllHHHHhhHHHHHHHHHHHHHHHLL> 1phr DFV..TFDYILCMDES....NLRDLNRKSNqvkNCRAKIELlgsydpqkqlIIEDPyygnDADFetVYQQCVRCCRAFLEKVR> | | | | 1vhr KLQklGITHVLNAAEGrsfmHVNTNANFYK...DSGITYLG.........iKANDT....QEFN..LSAYFERAADFIDQALA DSSP HHHhhLLLEEEELLLLllllLLLLLHHHHL...LLLLEEEE.........lLLLLL....LLLL..HHHHHHHHHHHHHHHHL *Z-score 6.3 AR 108 RMSD 3.9A SI 11% |
Structural alignment by DaliLite |