• Backbone structures are obtained using ProteinViewer, where N-terminal is colored red and C-terminal blue.
• Click the images to view larger image.
• Click PDB IDs to view the corresponding PDB file
• See the bottom for explanation of the DSSP codes and the 5-tile codes. 

(3) Rossmann Fold-like Domains of ATP-Grasp Proteins and Zinc-carboxypeptidase: Carboxypeptidase A (2ctc), Dala-dala Ligase (2dln), Biotin Carboxylase (1bnc), Synapsin (1auv), and Glutathione Synthase (1gsa)

2ctc (ResA58-307)	2dln (ResA1-306)	1bnc (ResA1-320)	1auv (ResA114-417)	1gsa (Res2-314)

2ctc  PAIWIDL    GI  H     SRE  WITQATGVWFA           K     KFTE               DY       G QD       PS code  0000000    RQ  G     QAB  QAAAAAAAAAA           A     AAAA               BG       Q G0       QA 2dln DKIAVLLGGTS  A          E  REVSLNSGAAV           L     AGLRE              GGIDAYPVDPK EVD     VTQL code B0000000000  Q          B  QAAAAAAAAAA           A     AAAAA              B00R00000QB 000     QABQ 1bnc  DKIV      IA   N  RGE I    ALRILRACKELGIKTVAVHSSADRDLKHVL  LADETVCIGPAPSVKS       YLN        IP code  0000      OR   G  001 A    AAAAAAAAAABR00000000QABQB0QAAA  GGR00003000GQAB0       QBG        QA 1auv  RVLLVIDE    P HTD         WAKY                                           FK GKK      I code  00000000    Q RGR         QAAA                                           B0 R00      0 1gsa  LGIVMDP     IA N IN  I KKDSSFAMLLEAQR                                    R           GYELHYMEMG code  0000000     QA G G0  Q B00QAAAAAAAAAA                                    B           00000000QA 2ctc FTAIL   D        S M DI FLEI V  T  NP   DGFAFT  H  SQ N    R                   L W RKT  R S code AAAAA   B        0 0 00 000R 0  R  0Q   AAAAAA  B  00 0    Q                   B 0 000  R 0 2dln KS      M        G FQKV FI ALHGRG  GEDGTLQGMLEL MG LP YTGSGVMASALSM DKLRSKLLWQGAGL PVA    P code AA      B        0 0R00 00 RG000R  0RGRHAAAAAAA BR 00 00000QHAAAAAA GQAAAAAAAAABR0 000    0 1bnc AIISAAEIT      G AVA IHPGYG  F  LSENA   NFAEQVERSGFIFIGPK  A ETIRLMGDKVSAIAAMKKAGV PCV    P code AAAAAAAAB      R 030 00R000  0  RR80Q   AAAAAAAABRG00R000  Q AAAAAABGQAAAAAAAAABR0 000    0 1auv          HGE     I D IK VEQ  A     EF   S       DL NL VAH  A                   NGG FSVDEVLRNGV code          RRG     0 0 00 000  0     0Q   A       BG 00 000  Q                   BR0 00003RG01RR 1gsa         D  LYLINGE A RAHTRT  L     N               VKQN    Y                   E EWFSF  V G code         B  G000RR0 0 00O000  0     0               00R0    Q                   B 0O000  R 0 2ctc VTS       SSLCVGV D        ANR            NWDA      G FG  K  A GA S  SS P        CSETY code 000       BGRG000 R        QAA            JGRG      R 0R  0  1 RG 0  RG Q        BGQB0 2dln WVALTRAEFEK   GLS          DKQLAEISA       L   GL PV  I   VKP  S  REGS S             V code 00000QAAAAB   000          QAAAAAAAA       G   00 00  0   000  R  001R R             0 1bnc GS          D GPLGDD       MDKNRAIAKR         IGYPVI  I KRGM code 00          R 0000RG       QAAAAAAAAA         B00O00  0 PJ00 1auv KVV           RSL K  P                      D  FV LIRQHA  FS  ARN GD Y  RSLVIGLQYA code 000           000 R  0                      R  00 00RG0R  00  3RG 00 R  QAAAAAAAAB 1gsa EQDLPLA   DLD VIL M RKDPPFDTEFIYATYILERAEE    KGT LI          V  NK     PQSLR    DC  NEKLFTAWFSDLTP code 00000QA   BGR 000 R O000OR0QAAAAAAAAAAAAAA    B00 00          3  O0     QAAAA    BG  0R1AAAAAGQABG0 2ctc HGKYA   NS  E    VEVKSIV   DFVKDHGN         FK   AF LSI  HSYS Q L L  LYP Y      GY T         T         Q code R0R00   RR  G    QAAAAAA   AAAAABRG         0R   00 000  0000 R 0 0  000 0      QB 0         R         G 2dln GM SKVVA     ENA LQDALRL   AFQ    H         DEE  VL IEK  WLS   GP E  FTV AI LG               E         E code R0 00000     QAB QAAAAAA   AAA    G         0RG  00 000  000   G0 0  000 00 00               R         G 1bnc  R VV   R  G DAEL AQSISM   TRAE A  K       MV    YM EKY  LENP   R H  VEI QV LAD GQ GNAIYLAERDCSM  QR RHQKVVEEAPAPG code  0 00   R  0 QABI AAAAAA   AAAA B  P       J0    00 000  0000   0 0  000 00 000 QB 0000000000RRB  00 RRG000000O00R 1auv GI PS   INS      LHSVYNFCDKPWVFAQ   VRLHKKL G  TEEFPLI N QTFY P NH KELSSTTYPVVVK  GHAH       S  GGKVK code R0 00   3 O0     QAAAAAABGQAAAAAB   QAAAAAB 0  QB00300 R 0000 R 0R RG000R00O0000  3000       R  13000 1gsa  E TLVT R   N    KAQLKAF   WE   K           HSD  II LKPLDG   MG  GAS IFR VK E                G code  0 0000 R   G    QAAAAAA   AA   B           0RG  00 000RG0   1R  R0R 000 00 0                R 2ctc S  I             P  D               KTELNQVAKSAVEA                LKS             LY G TS YKYGS       IIT T IYQAS code 0  0             Q  B               QAAAAAAAAAAAAA                AAA             G0 R 00 00000       QAB 0 00000 2dln I  LPSIRIQPSGTFYDYEAKYLSDETQYFCPAGLEASQEANLQALVLKA                WTT           L    G CKGWGRID           V MLDS code 0  00000000R0O0R0QAAB00GQBG0000ORR00QAAAAAAAAAAAAA                AAA           B    R 00R00000           0 000Q 1bnc I  T                                PELRRYIGERCAKA                CVD            I   G YR GAGTF           E FLFE code 0  0                                QAAAAAAAAAAAAA                AAA            8   R 00 00000           0 0000 1auv VD N                                QHDFQDIASVVAL T             K                 TYA  TT EPFI  D         AKYDVRIQKI code 0R 0                                QAAAAAAAAAAAA B             R                 G00  00 0000  R         0R00000000 1gsaDPN                                 LGVIAETL      TEHGTRYCMAQNYL PAIKDGDKRVLVVDG  EPVPYCL ARIPQGGETRGNLAAGG RGEPR code 0RH                                 QAAAAAAA      BRRRRG00000000 QAAAB0R000000RR  G00RG00 000000RGRGRGQABR0 00000 2ctc G  GS           IDWSYN         Q GI KY SF TF ELRDTGRY GFLLP                      ASQI  IPTAQ        ET     WLGVLTIMEHTL code R  0P           AAAAAA         B RR PB 00 00 0000R1RR 0QB00                      QABQ  AAAAA        AA     AAAAAAAAAAAA 2dln                                D G     QF YLLEAN T     S  PGMT                   S H SLVPMAA        RQAGMSFSQLVVRILE   L code                                B R     00 003000 R     0  0000                   Q B 01AAAAA        AABR00QAAAAAAAAA   B 1bncN                                G    EFY FI EMN T    RI  Q                      V EH  PVTEMITGV  DLIK     EQLRIA      AG code R                                R    G00 00 000 R    G0  0                      Q BQ  AAAAAGRR0  0QAA     AAAAAA      BR 1auv GQNYKAYRTLEQIASDRYKLWVDTCS     EIFG    GLDIC AVEA     L  HG   KDGRDHIIEVVG SSPLIGD HQ  DEDKQ        LI     VELVVNKA code RRG00000O300000QAAAAAAAAAA     BGRR    00R00 0000     0  00   QBRG00000000 R80000Q BQ  AAAAA        AA     AAAAAAAA 1gsa    PLT         ESDWKIARQIGPTLKEK GLI   FV GL DIIGD   RL  TEINV   TSP      TC        I  REIEA E FPVSITG     MLMDAIEAR code    000         QAAAAAAAAAAAAAAAB RRR   00 00 0000R   G0  0000O   G00      1R        Q  AAAAA 8 0RG0QAA     AAAAAAAAA *[2ctc-2dln] RATIO :  lcs/trimmed_seq_a = 0.724 (=  178/  246), lcs/trimmed_seq_b = 0.589 (=  178/  302) *[2ctc-1bnc] RATIO :  lcs/trimmed_seq_a = 0.703 (=  173/  246), lcs/trimmed_seq_b = 0.571 (=  173/  303) *[2ctc-1auv] RATIO :  lcs/trimmed_seq_a = 0.663 (=  163/  246), lcs/trimmed_seq_b = 0.591 (=  163/  276) *[2ctc-1gsa] RATIO :  lcs/trimmed_seq_a = 0.699 (=  172/  246), lcs/trimmed_seq_b = 0.557 (=  172/  309)

Structural alignment by ComSubstruct

DSSP LLLEEEEEELLLLL       L.HHHHHHHHHHHHHHHHHLlllhh 2ctc NRPAIWIDLGIHSR       E.WITQATGVWFAKKFTEDYgqdps          |   ||  |        |       |        | 2dln MTDKIAVLLGGTSA       ErEVSLNSGAAVLAGLREGG..... DSSP LLLEEEEELLLLLL       LhHHHHHHHHHHHHHHHHLL.....          | | 1bnc mlDKIVIANR....       . ...GEIALRILR........... DSSP llLEEEELLL....       . ...HHHHHHHHH...........                                  |    || | 1auv ..RVLLVIDE....       . ...PHTD..WAKYF........k DSSP ..LEEEEELL....       . ...LLLL..HHHHH........l          |                      | 1gsa ....IKLGI.VMDPianinikk DSSFAMLLEAQRRG......... DSSP ....LEEEE.ELLLhhhlllll LHHHHHHHHHHHLL......... DSSP hhhh  hhhlEEEEElLLLHhhhhhhhhllllllllllllllllllllllllllllllllllllllllllll 2ctc ftai  ldsmDIFLEiVTNPdgfafthsqnrlwrktrsvtssslcvgvdanrnwdagfgkagassspcsety                | 2dln ....  ...iDAYPV.DPKE.................................................... DSSP ....  ...lEEEEE.LLLL....................................................       1bnc .ack  elgIKTVAV..HSSADRD..................................lkhvlladetvcig DSSP .hhh  hllLEEEEE..EEHHHLL..................................lhhhhhlleeeeee         |  1auv GKKIhgeIDIKVEQA......................................................... DSSP LLLLlllLLLEEEEE.........................................................                   | 1gsa ....  .....YELH.YMEM.................................................... DSSP ....  .....LEEE.EELH.................................................... DSSP llllllllhhhH                         HHHh        HHHH           HlLEEEEEE.EEELlleeeelllllllllllhhhhhhhhhhhhhhhhhhhl 2ctchgkyansevevK                         SIVd        FVKD           HgNFKAFLS.IHSYsqlllypygyttqsipdktelnqvaksavealkslyg                                                         |               |       | 2dln...........V                         DVT.        QLKS           M.GFQKVFIaLHGR..................................... DSSP...........L                         LHH.        HLHH           H.LEEEEEElLLLL.....................................                                            |                          |   | 1bncpapsvksylNIP                         AIIS        AAEI           TG.AVAIHP GYG...................................... DSSP lllhhhlllLHH                         HHHH        HHHH           HL.LLEEEL LLL......................................                                                        |                    | 1auv.........efs                         DLNLvahanggfSVDXevlrngvkvvrSLKPDFVLI RQ....................................... DSSP .........lhh                         HEEEeellllleEEEEeelllllleeeEELLLEEEE LL.......................................       1gsa ........GDLYlingearahtrtlnvkqnyeewfsfvgeQ        DLP.           ..laDLDVI LMR...................................... DSSP ........HHEEeelleeeeeeeeeeellllllleeeeeeE        EEE.           ..hhHLLEE EEL...................................... DSSP llleeeehhhhlll  lllL HHHHHHHLLLlEEEE............................................................................. 2ctc tsykygsiittiyq  asgG SIDWSYNQGIkYSFT.............................................................................                                   | 2dln ............gg  edgT LQGMLELMGL.PYTGsgvmasalsmdklrskllwqgaglpvapwvaltraefekglsdkqlaeisalglpvivkpsregssvgmskvvaena DSSP ............ll  llhH HHHHHHHHLL.LLLLllhhhhhhhhlhhhhhhhhhhllllllleeeeehhhhhlllllllhhhhhllllleeeeellllllllleeellhhh                                   | 1bnc ...........fls  enaN FAEQVERSGF.IFIGpkaetirlmgdkvsaiaamkkagvpcvpgsdgplgddmdknraiakrigypviikrgmrvvrgdaelaqsismtrae DSSP ...........lll  llhH HHHHHHHLLL.EELLllhhhhhhhhlhhhhhhhhhhhlllllllllllllllhhhhhhhhhhhllleeellllleellhhhhhhhhhhhhll                                   ||  | 1auv .....haFSXARNG  DyRS LVIGLQYAGI.PSINslhsvynfcdkpwvfaqxvrlhkklgteefplinqtfypnhkexlssttypvvvkxghahsgxgkvkvdnqhdfqdi DSSP .....llEELLLLE  ElHH HHHHHHHLLL.LEELlhhhhhhlllhhhhhhhhhhhhhhhlllllllllleeellhhhlllllllleeeeelllllllleeeellhhhhhhh                                     | 1gsa .......kdpPFDTefIYATyILERAEE...KGTLI DSSP .......lllLLLHhhHHHHhHHHHHHH...LLLEE DSSP ......................................................................................................... 2ctc .........................................................................................................       2dln lqdalrlafqhdeevliekwlsgpeftvailgeeilpsiriqpsgtfydyeakylsdetqyfcpagleasqeanlqalvlkawttlgckgwgridvmldsdgqfy DSSP hhhhhhhhhlllleeeeeellllleeeeeeelleellleeeelllllllhhhhhllllleeellllllllhhhhhhhhhhhhhhhhlllleeeeeeeelllllee       1bnc akmvymekylenprhveiqvladgqgnaiylaerdcsmqrrhqkvveeapapgitpelrryigercakacvdigyrgagtfeflfengefyfiemnt DSSP llllleeellllleeeeeeeeeelllleeeeeeeellllllllllllllllllllhhhhhhhhhhhhhhhhhhlleeeeeeeeeeelleeeeeeeel       1auv asvvaltktyattepfidakydvriqkigqnykayxrtleqiaxsdryklwvdtcseifggldicavealhgkdgrdhiievvg DSSP hhhhhllllleeeeellleeeeeeeeeelleeeeeeelleeelllhhhhhhhhhhllhhhllleeeeeeeeelllleeeeeeel       1gsa DSSP  DSSP ee 2ctc fe       2dln ll DSSP ee       1bnc RI DSSP LL       1auv SS DSSP LL       1gsa VNkpqslrdcneklftawfsdltpetlvtrnkaqlkafwekhsdiilkpldgmggasifrvkegdpnlgviaetltehgtrycmaqnylpaikdgdkrvlvvdgepvpyclari DSSP ELlhhhhhhllllhhhhhhlllllleeeellhhhhhhhhhhhlleeeelllllllllleeellllllhhhhhhhhllllllleeeeellhhhhhleeeeeeelleelleeeeee DSSP                                                        elllllllllllhhhhhh  hhhhhhhhhhhhhhhhhhl 2ctc                                                        lrdtgrygfllpasqiip  taqetwlgvltimehtlnn       2dln                                                        eantspgmtshslvpmaa  rqagmsfsqlvvrilelad DSSP                                                        eeelllllllllhhhhhh  hhllllhhhhhhhhhhlll       1bnc                                                        QVE..........hPVTEmitgvDLIKEQLRIAAG..qp DSSP                                                        LLL..........hHHHHhhhllLHHHHHHHHHLL..ll                                                                                        | | 1auv                                                        XP...........lIGDH  QDEDKQLIVELVVNKXAQA DSSP                                                        LL...........lLLLL  HHHHHHHHHHHHHHHHHLL       1gsa pqggetrgnlaaggrgeprpltesdwkiarqigptlkekglifvgldiigdrlteinvtsptcireieaefpvS  ITGMLMDAIEARLQ..... DSSP lllllllllhhhlleeeeeellhhhhhhhhhhhhhhhhlllleeeeeeelleeeeeellllllhhhhhhhlllL  HHHHHHHHHHHHLL..... *[2ctc-2dln] Z-score 2.9  AR 77  RMSD 3.0A  SI 16% *[2ctc-1bnc] Z-score 1.8  AR 88  RMSD 3.8A  SI  9% *[2ctc-1auv] Z-score 3.3  AR 94  RMSD 3.3A  SI 13% *[2ctc-1gsa] Z-score 2.4  AR 84  RMSD 3.9A  SI  5%

Structural alignment by DaliLite

[The DSSP code]

• H = alpha helix
• B = residue in isolated beta-bridge
• E = extended strand, participates in beta ladder
• G = 3-helix (3/10 helix)
• I = 5 helix (pi helix)
• T = hydrogen bonded turn
• S = bend
• L = no assigned structure

[The 5-tile code]

• 0 = DDDDD    (extended strand, small blue spheres)
• 1 = DDDDU
• 2 = DDDUD
• 3 = DDDUU
• 8 = DUDDD
• 9 = DUDDU
• A = DUDUD    (helix, large red spheres)
• B = DUDUU    (turn, large yellow spheres)
• G = UDDDD
• H = UDDDU
• I = UDDUD
• J = UDDUU
• O = UUDDD
• P = UUDDU
• Q = UUDUD    (turn, large yellow spheres)
• R = UUDUU    (turn, large yellow spheres)