Superfolds are the protein folds known to recur in proteins having neither sequence nor functional similarity. And they are much common than other folds [1].

Frequency of occurrence of the DSSP code / 5-tile code / PB fragments among the nine superfolds given below

(1thbA, 256bA, 1aps, 1ubq, 2fox, 7timA, 1ilb, 2buk, and 2rhe)

DSSP code / 5-tile code / PB sequences

  1. Globin-like (1thb A and B)

  2. Up-down (256b A)

  3. Alpha-beta-plait (1aps)

  4. UB rolls (1ubq)

  5. Doubly wound (2fox)

  6. TIM barrel (7tim A)

  7. Trefoil (1ilb)

  8. Jelly roll (2buk)

  9. IG-like (2rhe)

  1. C.A. Orengo, D.T. Jones, and J.M. Thornton, Protein superfamilies and domain superfolds. Nature 372, 631-634 (1994).
  2. de Brevern A.G., Etchebest C. and Hazout S., Bayesian probabilistic approach for prediction backbone structures in terms of protein blocks, Proteins, 41, 271-287 (2000).
  3. W. Kabsh and C. Sander , Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers 22, 2577-2637 (1983).

  1. Protein Blocks Expert Home: http://bioinformatics.univ-reunion.fr/PBE
  2. MSD-EBI (for the DSSP code of proteins in the PDB): http://www.ebi.ac.uk/msd